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Poorly Differentiated Thyroid Carcinoma with Gross Internal Jugular Vein Invasion and Multiple Lung Metastases
Clin Exp Thyroidol 2015;8(1):103-107
Published online May 30, 2015
© 2015 Korean Thyroid Association.

Yong-Moon Lee1, Jae Hyun Park2, Junjeong Choi3, Keum-Seok Bae2 and Seong Joon Kang2

Department of Pathology1, Chungbuk National University College of Medicine, Cheongju, Departments of Surgery2 and Pathology3, Yonsei University Wonju College of Medicine, Wonju, Korea
Received April 7, 2014; Revised August 11, 2014; Accepted August 13, 2014.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A rare case of poorly differentiated thyroid carcinoma (PDTC) with gross intraluminal invasion to the internal jugular vein whose clinical manifestation was multiple lung metastases is described. A 66-year-old man was referred to the outpatient clinic of the Department of Internal Medicine, hemato-oncology subdivision for multiple lung nodules found by his regular health check-up. These lung nodules showed variable sizes with irregular shapes, and typical distributions throughout the parenchyma, which were consistent with metastatic nodules. Ultrasonography revealed a 4.5 cm sized hypoechoic mass with irregular shape in his left thyroid lobe and a huge thrombus in the left internal jugular vein. PDTCs associated with gross intraluminal invasion to the great cervical vein and multiple lung nodules as their first clinical manifestation are extremely rare. We would emphasize the importance of preoperative detailed evaluation of the disseminated disease by ultrasonography in suspected patients.
Keywords : Poorly differentiated thyroid carcinoma, Internal jugular vein, Lung, Invasion, Metastasis

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