Effect of Prolonged TSH Suppression on Cardiovascular System
Jong-Min Song, MD, PhD
Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.- Abstract
- Prolonged thyroid-stimulating hormone (TSH) suppression caused by exogenous subclinical thyrotoxicosis has been reported to impose harmful effects on cardiovascular system. Those effects involve increase in heart rate and myocardial mass, impaired ventricular diastolic and systolic function, decreased exercise capacity, decreased arterial elasticity, development of atrial tachyarrhythmia, and increase in cardiovascular adverse events. Tailored dose adjustment of thyroid hormone under the guidance of TSH level for obviating oversuppression of TSH, and use of beta blockers can reduce cardiovascular adverse effects in patients who undergo thyroid hormone therapy.
- Keywords : Cardiovascular system, Thyrotoxicosis, Thyrotrophs
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