The cases of methimazole-induced insulin autoimmune syndrome in Graves’ disease in Korea
| Case 13) | Case 24) | Case 35) | Case 46) | Case 57) | Our case | |
|---|---|---|---|---|---|---|
| Age/sex | 36/female | 29/male | 15/female | 52/female | 53/female | 48/female |
| MMI dose (duration) | NA (4 weeks) | NA (3 weeks) | NA (4 months) | 30 mg (4 weeks) | 40 mg (4 weeks) | 20 mg (6 months) |
| Anti-insulin antibody (U/mL) | 150 | 300 | >100 | 84.7 | 84.8 | 96.7 |
| HLA alleles | NA | NA | HLA-DRB1*04:06 | NA | HLA-DRB1*0406, *1501 | NA |
| Treatment of Graves’ disease | Stop MMI, RI | Stop MMI, RI | MMI | Stop MMI, RI | Stop MMI, RI | Stop MMI, PTU |
| Treatment of hypoglycemia | Diet | Diet | Steroid | Diet | Diet | Diet |
HLA: human leukocyte antigen, MMI: methimazole, NA: not available, PTU: propyl thiouracil, RI: radioactive iodine