International Journal of Thyroidology

Table. 1.

Table. 1.

Application of nerve guided conduits in RLNI animal models

Animal Materials Application Results Reference
SD rat SCs, NSCs, laminin-chitosan-PLGA/NGC 5 mm long laminin-chitosan-PLGA/NGC containing SCs/NSCs was sutured between nerve stumps The repair effect of SCs and NSCs in the laminin-chitosan-PLGA/NGC was best in the article, even better than the autograft group Li et al.25)
SD rat Microgroove PLGA/NGC Microgroove PLGA/NGC was sutured between a 5 mm nerve gap Microgroove PLGA/NGC was superior to smooth PLGA/NGC in nerve regeneration and had similar effects to the autograft group in reducing muscle atrophy and restoring function Yang et al.18)
New Zealand white rabbit SWNTs, PEDOT:PSS coated PCL/NGC SWNTs, PEDOT:PSS coated PCL/NGC was sutured between a 10 mm nerve gap SWNTs, PEDOT:PSS coated PCL/NGCs showed an improved tendency of vocal cord mobility Choi et al.19)
New Zealand white rabbit PCL/F127 NGC PCL/F127 NGC was sutured between a 10 mm nerve gap PCL/F127 NGC showed improved vocal cord movement, thyroarytenoid muscle status, and nerve regeneration Choi et al.20)
New Zealand white rabbit PRP-loaded PCL/F127 NGC PRP-loaded PCL/F127 NGC was sutured between a 10 mm nerve gap RLN functional regeneration of PRP-loaded PCL/F127 NGC produced better results than that of non-loaded PCL/F127 NGC Kim et al.22)
SD rat Collagen gel containing silicone tube Collagen gel containing silicon tube was sutured between 1, 3 or 5 mm nerve gap Temporary recovery of vocal fold movement by bridging the transected RLN with silicone tube containing collagen gel Asai et al.24)
SD rat BDNF, GDNF, LBDs, collagen scaffold Collagen scaffold loaded with laminin, LBD-BDNF and LBD-GDNF Nerve fiber regeneration, muscle action potentials and vocalization were better in the experimental groupthan in the autologous nerve graft group Wang et al.23)
SD rat PGA-coated tube Tube was inserted into two nerve stumps Vocal cord mobility was higher in the experimental group Şentürk et al.21)
SD rat RADA16-I hydrogel, silicone tube 8 mm silicone tube bridged a 6 mm nerve gap Myelinated nerve and thyroarytenoid muscle area were large in the RADA16-I hydrogel group Yoshimatsu et al.26)

BDNF: brain-derived neurotrophic factor, GDNF: glial cell line-derived neurotrophic factor, LBDs: laminin-binding domains, NGC: nerve guided conduit, NSCs: neural stem cells, PCL/F127: polycaprolactone/pluronic F127, PEDOT:PSS: poly (3,4-ethylenedioxythiophene):polystyrene sulfonate, PGA: polyglycolic acid, PLGA: poly-lactic-co-glycolic acid, PRP: platelet rich plasma, RADA16-I: a self-assembling peptide, RLNI: recurrent laryngeal nerve injury, SCs: Schwann cells, SD rat: Sprague-Dawley rats, SWNTs: single-walled carbon nanotubes

Int J Thyroidol 2023;16:96-100
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