Application of nerve guided conduits in RLNI animal models
| Animal | Materials | Application | Results | Reference |
|---|---|---|---|---|
| SD rat | SCs, NSCs, laminin-chitosan-PLGA/NGC | 5 mm long laminin-chitosan-PLGA/NGC containing SCs/NSCs was sutured between nerve stumps | The repair effect of SCs and NSCs in the laminin-chitosan-PLGA/NGC was best in the article, even better than the autograft group | Li et al.25) |
| SD rat | Microgroove PLGA/NGC | Microgroove PLGA/NGC was sutured between a 5 mm nerve gap | Microgroove PLGA/NGC was superior to smooth PLGA/NGC in nerve regeneration and had similar effects to the autograft group in reducing muscle atrophy and restoring function | Yang et al.18) |
| New Zealand white rabbit | SWNTs, PEDOT:PSS coated PCL/NGC | SWNTs, PEDOT:PSS coated PCL/NGC was sutured between a 10 mm nerve gap | SWNTs, PEDOT:PSS coated PCL/NGCs showed an improved tendency of vocal cord mobility | Choi et al.19) |
| New Zealand white rabbit | PCL/F127 NGC | PCL/F127 NGC was sutured between a 10 mm nerve gap | PCL/F127 NGC showed improved vocal cord movement, thyroarytenoid muscle status, and nerve regeneration | Choi et al.20) |
| New Zealand white rabbit | PRP-loaded PCL/F127 NGC | PRP-loaded PCL/F127 NGC was sutured between a 10 mm nerve gap | RLN functional regeneration of PRP-loaded PCL/F127 NGC produced better results than that of non-loaded PCL/F127 NGC | Kim et al.22) |
| SD rat | Collagen gel containing silicone tube | Collagen gel containing silicon tube was sutured between 1, 3 or 5 mm nerve gap | Temporary recovery of vocal fold movement by bridging the transected RLN with silicone tube containing collagen gel | Asai et al.24) |
| SD rat | BDNF, GDNF, LBDs, collagen scaffold | Collagen scaffold loaded with laminin, LBD-BDNF and LBD-GDNF | Nerve fiber regeneration, muscle action potentials and vocalization were better in the experimental groupthan in the autologous nerve graft group | Wang et al.23) |
| SD rat | PGA-coated tube | Tube was inserted into two nerve stumps | Vocal cord mobility was higher in the experimental group | Şentürk et al.21) |
| SD rat | RADA16-I hydrogel, silicone tube | 8 mm silicone tube bridged a 6 mm nerve gap | Myelinated nerve and thyroarytenoid muscle area were large in the RADA16-I hydrogel group | Yoshimatsu et al.26) |
BDNF: brain-derived neurotrophic factor, GDNF: glial cell line-derived neurotrophic factor, LBDs: laminin-binding domains, NGC: nerve guided conduit, NSCs: neural stem cells, PCL/F127: polycaprolactone/pluronic F127, PEDOT:PSS: poly (3,4-ethylenedioxythiophene):polystyrene sulfonate, PGA: polyglycolic acid, PLGA: poly-lactic-co-glycolic acid, PRP: platelet rich plasma, RADA16-I: a self-assembling peptide, RLNI: recurrent laryngeal nerve injury, SCs: Schwann cells, SD rat: Sprague-Dawley rats, SWNTs: single-walled carbon nanotubes