The American College of Physician (ACP) guideline grading system
Strength of recommendation | Strong | Benefits clearly |
Weak | Benefits are finely balanced with risks | |
Quality of evidence | High-quality | 1 or more well-designed and well-executed randomized, controlled trials (RCTs) |
Moderate | RCTs with important limitations/well-designed cohort or case–control | |
Low | Observational studies |