Progression from Hashimoto’s thyroiditis to Graves’ disease: Case 1
| Age | TSH μU/mL (0.3-4) |
Free T4 ng/dL (0.77-1.94) |
T3 ng/mL (0.75-1.9) |
TBII IU/L (0-1.5) |
Anti-TPO antibody U/mL (0-60) |
Anti-Tg antibody U/mL (0-60) |
LT dose (mg) | MM dose (mg) |
|---|---|---|---|---|---|---|---|---|
| 7 y, 6 m | 5.07 | 1.33 | 1.09 | Nd |
1.15 | 167.44 | 0.05 |
- |
| 10 y, 5 m |
0.005 | 3.3 | Nd | 3.07 | 122.61 | 509.41 | D/C |
10 b.i.d. |
| 11 y, 2 m | 6.30 | 1.19 | 1.25 | 1.40 | 168.82 | Nd | D/C | 2.5 q.d. |
| 11 y, 10 m | 0.02 | 3.55 | 2.72 | 79.34 | 1626.8 | Nd | D/C | 10 b.i.d. |
| 12 y, 10 m | 0.01 | 1.75 | 1.87 | Nd | Nd | Nd | D/C | 15 b.i.d. |
| 12 y, 11 m | 0.01 | 1.83 | 2.23 | Nd | Nd | Nd | D/C | 15 b.i.d. |
*Nd: not done
†There were no clinical symptoms. After 8 months without medication, she developed goiter and was prescribed levothyroxin.
‡Laboratory tests were performed at another clinic. Reference ranges are as follows: TSH, 0.4-4.2 μU/mL free T4 0.8-1.9 ng/dL; TBII-positive, ≥1.75 IU/L; anti-Tg Ab-negative, <4.11 U/mL; anti-TPO Ab-negative, <5.61 U/mL.
§D/C: discontinue
∥In combination with propranolol.
¶q.d.: q1d, every day
**In combination with propranolol (10 mg b.i.d.), at this time goiter is aggravated.