Clinical course and laboratory findings in the two cases
| Case no |
Age | Free T4 (ng/dL) [Reference] |
TSH (μU/mL) [Reference] |
Ht/Wt (cm/kg) |
Dx | Tx course (Dose μg/kg) |
|---|---|---|---|---|---|---|
| 1 | NST | 36.1 [0.5-10] | ||||
| 2 wk | 0.5 [0.9-2.6] | >150 [0.5-10] | Start T4 12.5 | |||
| 2.8 yr | 1.51 [0.8-2.2] | 0.45 [0.5-4.8] | 91/14 | On T4 3.57 | ||
| 3.1 yr | 0.95 | 16.4 | ND/15.2 | RI | After trial-off | |
| 3.6 yr | 1.42 | 0.84 | Restart T4 3.36 | |||
| 4.1 yr | 1.14 | 1.71 | 100.1/16.4 | On T4 3.05 | ||
| 4.6 yr | 0.99 | 5.16 | US | After trial-off | ||
| 5.1 yr | 1.05 | 2.31 | ND/18 | Off T4 | ||
| 6.0 yr | 0.8 | 12.28 | 114.6/19.9 | Off T4 | ||
| 6.1 yr | 1.05 | 2.31 | Restart T4 1.39 | |||
| 7.0 yr | 1.29 | 0.93 | 120.7/24.9 | NGS | On T4 1.00 | |
| 2 | NST | 3.3 |
76.3 [0.5-10.0] | ND/2.9 | ||
| 2 wk | 0.29 [0.9-2.6] | >50 [0.5-10.0] | 50.6/3.4 | Start T4 9.71 | ||
| 1.5 yr | 1.75 [0.8-2.2] | 1.62 [0.5-4.8] | 85/12 | On T4 2.08 | ||
| 2.1 yr | 1.9 | 9.76 | 92/13 | RI | After trial-off | |
| 2.5 yr | 1.0 | 9.0 | ND/14 | Off T4 | ||
| 3.0 yr | 1.1 | 8.6 | Off T4 | |||
| 4.1 yr | 0.58 | 28.8 | 100.7/16.5 | RI | Off T4 | |
| 4.3 yr | 1.78 | 0.38 | 102.7/17 | Restart T4 3.03 | ||
| 14.5 yr | 1.22 [0.8-2.3] | 1.58 | 156.8/50.6 | US, NGS | On T4 0.98 |
Dx: diagnostics, Free T4: free thyroxine, Ht/Wt: height/weight, ND: no data, NGS: next-generation sequencing, NST: neonatal screening test, RI: radionuclide scan, T4: levothyroxine, TSH: thyroid-stimulating hormone, Tx: treatment, US: ultrasound scan, wk: weeks, yr: years
*Total T4 (μg/dL).