International Journal of Thyroidology

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Table. 4.

Table. 4.

Comparisons of the group from TCGA THCA

Characteristics NCOR1/THRA n=24 (%) SMRT/THRB n=24 (%) p-value
Ras driver mutation 0.018
Absent 18 (78.3) 23 (100.0)
Present 5 (21.7) 0 (0.0)
BRAF driver mutation 0.376
Absent 13 (56.5) 10 (43.5)
Present 10 (43.5) 13 (56.5)
TERT promoter mutation 0.086
Absent 16 (94.1) 13 (72.2)
Present 1 (5.9) 5 (27.8)
RAS/RAF score −0.024±0.71 −0.78±0.23 <0.0001*
ERK score −2.08±18.29 24.25±14.04 <0.0001*
Differentiation score 0.37±1.08 −0.87±1.01 <0.0001*
Tumor status 0.130
Free 23 (100.0) 19 (90.5)
With tumor 0 (0.0) 2 (9.5)

*p-values calculated using Student’s t-test. Data are mean±SD.

p-values calculated using χ2 test or linear-by-linear association.

NCOR1: nuclear receptor co-repressor 1, SMRT: silencing mediator for retinoid or thyroid hormone receptor, SD: standard deviation, TCGA: The Cancer Genome Atlas, THCA: thyroid cancer, THRA: thyroid hormone receptor alpha, THRB: thyroid hormone receptor beta

Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152
© 2021 Int J Thyroidol