International Journal of Thyroidology

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Table. 3.

Table. 3.

Comparison of the clinico-pathological characteristics between the high NCOR1/THRA group and high SMRT/THRB group from TCGA THCA

Characteristics NCOR1/THRA n=24 (%) SMRT/THRB n=24 (%) p-value
Age (years) 48.36±14.56 52.78±16.98 0.356*
Gender (Male:Female) 3 (12.5):21 (87.5) 10 (41.7):14 (58.3) 0.023
Tumor size (cm) 2.68±1.50 3.02±1.38 0.475*
MACIS score 5.16±1.24 6.05±2.01 0.097*
Histologic subtype 0.172
Follicular variant 4 (18.2) 1 (4.3)
Conventional 17 (77.3) 18 (78.3)
Tall cell variant 0 (0.0) 4 (17.4)
Othersς 1 (4.5) 0 (0.0)
Extrathyroidal extension 0.028
No 19 (82.6) 12 (52.2)
Yes 4 (17.4) 11 (47.8)
Multifocality 0.555
No 11 (47.8) 13 (56.5)
Yes 12 (52.2) 10 (43.5)
T stage 0.038
T1 9 (39.1) 3 (13.0)
T2 7 (30.4) 7 (30.4)
T3 6 (26.1) 11 (47.8)
T4 1 (4.3) 2 (8.7)
N stage 0.001
N0 17 (81.0) 7 (31.8)
N1 4 (19.0) 15 (68.2)
M stage 0.309
M0 14 (100.0) 13 (92.9)
M1 0 (0.0) 1 (7.1)
TNM stage 0.038
I 14 (63.6) 9 (39.1)
II 3 (13.6) 2 (8.7)
III 4 (18.2) 7 (30.4)
IV 1 (4.5) 5 (21.7)

*p-values calculated using Student’s t-test. Data are mean±SD.

p-values calculated using χ2 test or linear-by-linear association.

ςOthers: columnar cell variant, diffuse sclerosing variant, cribriform-morular variant, etc.

NCOR1: nuclear receptor co-repressor 1, MACIS: distant metastasis, patient age, completeness of resection, local invasion, and tumor size, SMRT: silencing mediator for retinoid or thyroid hormone receptor, SD: standard deviation, TCGA: The Cancer Genome Atlas, THCA: thyroid cancer, THRA: thyroid hormone receptor alpha, THRB: thyroid hormone receptor beta, TNM: tumor-node-metastasis

Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152
© 2021 Int J Thyroidol