International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Fig. 3.

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Fig. 3. TRβ dependent upregulation of HIF1A target genes in PTC. (A) Correlation between expression levels of THRA, THRB and HIF1A in TCGA (The Cancer Genome Atlas) THCA (thyroid carcinoma). (B) Representative results of reverse transcription-polymerase chain reaction (RT-PCR) indicating the effect of T3 on HIF1A target genes. (C) Representative results of RT-PCR showing the silencing efficacy effect of siTHRA and siTHRB. (D) Representative results of RT-PCR showing the effect of THRA, THRB silencing on the expression of HIF1A target genes in BCPAP cells. HIF1A: hypoxia inducible factor1 alpha, T3: triiodothyronine, THRA: thyroid hormone receptor alpha, THRB: thyroid hormone receptor beta. All experiments were repeated three times, and each experiment was performed in triplicate. Correlation coefficients were calculated by Pearson’s method.
Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152
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