International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Table. 2.

Table. 2.

Clinicopathological characteristics of TCGA THCA dataset according to THRB expression status

Characteristics THRB p-value

Low expression n=126 (%) High expression n=126 (%)
NCOR1 expression 94.22±37.54 120.88±34.07 <0.0001*
SMRT expression 141.19±38.16 176.54±49.18 <0.0001*
Age (years) 43.62±13.84 49.29±15.88 0.004*
Gender (Male:Female) 28 (22.2):98 (77.8) 25 (19.8):101 (80.2) 0.643
Tumor size (cm) 3.00±1.64 2.97±1.61 0.893*
MACIS score 5.01±1.42 5.64±1.65 0.003*
Histologic subtype 0.047
Follicular variant 29 (23.0) 20 (16.0)
Conventional 92 (73.0) 90 (72.0)
Tall cell variant 3 (2.4) 15 (12.0)
Othersς 2 (1.6) 0 (0.0)
Extrathyroidal extension 0.005
No 92 (78.6) 69 (61.6)
Yes 25 (21.4) 43 (38.4)
Multifocality 0.276
No 66 (54.1) 75 (61.0)
Yes 56 (45.9) 48 (39.0)
T stage 0.129
T1 35 (29.4) 32 (27.4)
T2 49 (41.2) 37 (31.6)
T3 32 (26.9) 41 (35.0)
T4 3 (2.5) 7 (6.0)
N stage 0.065
N0 63 (57.8) 46 (45.1)
N1 46 (42.2) 56 (54.9)
M stage 0.941
M0 63 (95.5) 67 (95.7)
M1 3 (4.5) 3 (4.3)
TNM stage 0.040
I 74 (62.2) 56 (47.9)
II 11 (9.2) 13 (11.1)
III 23 (19.3) 34 (29.1)
IV 11 (9.2) 14 (12.0)

*p-values calculated using Student’s t-test. Data are mean±SD.

p-values calculated using χ2 test or linear-by-linear association.

ςOthers: columnar cell variant, diffuse sclerosing variant, cribriform-morular variant, etc.

NCOR1: nuclear receptor co-repressor 1, MACIS: distant metastasis, patient age, completeness of resection, local invasion, and tumor size, SMRT: silencing mediator for retinoid or thyroid hormone receptor, SD: standard deviation, TCGA: The Cancer Genome Atlas, THCA: thyroid cancer, THRB: thyroid hormone receptor beta, TNM: tumor-node- metastasis

Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152
© 2021 Int J Thyroidol