International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Table. 1.

Table. 1.

Clinicopathological characteristics of TCGA THCA dataset according to THRA expression status

Characteristics THRA p-value

Low expression n=126 (%) High expression n=126 (%)
NCOR1 expression 112.33±35.59 103.92±43.00 0.092*
SMRT expression 167.14±41.05 153.82±40.66 0.010*
Age (years) 46.64±17.22 49.56±15.84 0.180*
Gender (Male:Female) 34 (27.0):92 (73.0) 34 (27.0):92 (73.0) 0.999
Tumor size (cm) 3.02±1.64 2.99±1.75 0.960*
MACIS score 5.59±1.66 5.30±1.38 0.173*
Histologic subtype <0.0001
Follicular variant 5 (4.0) 37 (30.3)
Conventional 100 (80.6) 80 (65.6)
Tall cell variant 18 (14.5) 2 (1.6)
Othersς 1 (0.8) 3 (2.5)
Extrathyroidal extension <0.0001
No 65 (57.5) 89 (80.2)
Yes 48 (42.5) 22 (19.8)
Multifocality 0.048
No 73 (58.9) 55 (46.2)
Yes 51 (41.1) 64 (53.8)
T stage 0.013
T1 27 (23.3) 38 (32.8)
T2 33 (28.4) 41 (35.3)
T3 48 (41.4) 33 (28.4)
T4 8 (6.9) 4 (3.4)
N stage <0.0001
N0 36 (33.0) 64 (64.6)
N1 73 (67.0) 35 (35.4)
M stage 0.480
M0 69 (98.6) 59 (96.7)
M1 1 (1.4) 2 (3.3)
TNM stage 0.127
I 63 (53.8) 62 (54.4)
II 5 (4.3) 20 (17.5)
III 33 (28.2) 25 (21.9)
IV 16 (13.7) 7 (6.1)

*p-values calculated using Student’s t-test. Data are mean±SD.

p-values calculated using χ2 test or linear-by-linear association.

ςOthers: columnar cell variant, diffuse sclerosing variant, cribriform-morular variant, etc.

NCOR1: nuclear receptor co-repressor 1, MACIS: distant metastasis, patient age, completeness of resection, local invasion, and tumor size, SMRT: silencing mediator for retinoid or thyroid hormone receptor, SD: standard deviation, TCGA: The Cancer Genome Atlas, THCA: thyroid cancer, THRA: thyroid hormone receptor alpha, TNM: tumor-node- metastasis

Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152
© 2021 Int J Thyroidol