International Journal of Thyroidology

Table. 1.

Table. 1. Table 1

Clinicopathological characteristics of TCGA THCA dataset according to THRA expression status

Characteristics	THRA		p-value

	Low expression n=126 (%)	High expression n=126 (%)
NCOR1 expression	112.33±35.59	103.92±43.00	0.092*
SMRT expression	167.14±41.05	153.82±40.66	0.010*
Age (years)	46.64±17.22	49.56±15.84	0.180*
Gender (Male:Female)	34 (27.0):92 (73.0)	34 (27.0):92 (73.0)	0.999^†
Tumor size (cm)	3.02±1.64	2.99±1.75	0.960*
MACIS score	5.59±1.66	5.30±1.38	0.173*
Histologic subtype			<0.0001^†
Follicular variant	5 (4.0)	37 (30.3)
Conventional	100 (80.6)	80 (65.6)
Tall cell variant	18 (14.5)	2 (1.6)
Others^ς	1 (0.8)	3 (2.5)
Extrathyroidal extension			<0.0001^†
No	65 (57.5)	89 (80.2)
Yes	48 (42.5)	22 (19.8)
Multifocality			0.048^†
No	73 (58.9)	55 (46.2)
Yes	51 (41.1)	64 (53.8)
T stage			0.013^†
T1	27 (23.3)	38 (32.8)
T2	33 (28.4)	41 (35.3)
T3	48 (41.4)	33 (28.4)
T4	8 (6.9)	4 (3.4)
N stage			<0.0001^†
N0	36 (33.0)	64 (64.6)
N1	73 (67.0)	35 (35.4)
M stage			0.480^†
M0	69 (98.6)	59 (96.7)
M1	1 (1.4)	2 (3.3)
TNM stage			0.127^†
I	63 (53.8)	62 (54.4)
II	5 (4.3)	20 (17.5)
III	33 (28.2)	25 (21.9)
IV	16 (13.7)	7 (6.1)

*p-values calculated using Student’s t-test. Data are mean±SD.

^†p-values calculated using χ² test or linear-by-linear association.

^ςOthers: columnar cell variant, diffuse sclerosing variant, cribriform-morular variant, etc.

NCOR1: nuclear receptor co-repressor 1, MACIS: distant metastasis, patient age, completeness of resection, local invasion, and tumor size, SMRT: silencing mediator for retinoid or thyroid hormone receptor, SD: standard deviation, TCGA: The Cancer Genome Atlas, THCA: thyroid cancer, THRA: thyroid hormone receptor alpha, TNM: tumor-node- metastasis

Int J Thyroidol 2021;14:152-69 https://doi.org/10.11106/ijt.2021.14.2.152