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Baseline characteristics of the study population (n=115)
| Variable | Value |
|---|---|
| Age, years (mean±SD) | 50.22±14.24 |
| Sex, female (%) | 72 (62.6) |
| Size, cm (mean±SD) | 1.89±1.46 |
| Multifocal tumors, number (%) | 23 (20.0) |
| Bilateral tumors, number (%) | 18 (15.7) |
| RET mutation, number (%) | |
| Positive | 16/76 (21.1) |
| Negative | 60/76 (78.9) |
| T stage, number (%) | |
| 1a | 40 (34.8) |
| 1b | 27 (23.5) |
| 2 | 19 (16.5) |
| 3a | 7 (6.1) |
| 3b | 13 (11.3) |
| 4a | 9 (7.8) |
| N stage, number (%) | |
| 0 | 47 (40.9) |
| 1a | 18 (15.6) |
| 1b | 50 (43.5) |
| AJCC 8th stage, number (%) | |
| I | 37 (32.2) |
| II | 10 (8.7) |
| III | 18 (15.6) |
| IVA | 50 (43.5) |
| Preoperative serum calcitonin, pg/mL | |
| Mean | 1,188 |
| Median | 336 |
| Range | 4-17,200 |
| Preoperative serum CEA, ng/mL | |
| Mean | 32.3 |
| Median | 6.4 |
| Range | 0.5-475.7 |
| Follow-up duration, years | |
| Median (IQR) | 8.3 (4.9-10.8) |
| Clinical outcome, number (%) | |
| No evidence of structural recurrence confirmed by sonography | 80 (69.6%) |
| Local metastasis confined to neck lymph nodes | 15 (13.0%) |
| Distant metastasis confirmed by CT or PET scans | 13 (11.3%) |
| Death | 7 (6.1%) |
AJCC: American Joint Committee on Cancer, CEA: carcinoembryonic antigen, CT: computerized tomography, IQR: interquartile range, MTC: medullary thyroid carcinoma, PET: positron emission tomography, SD: standard deviation