International Journal of Thyroidology

Table. 1. Table 1

Current results of studies about gut microbiome in patients with Graves’disease

1° Author Country, year	Method	Numbers of patients (Controls)	Indices of gut microbial diversity in patients	Increased bacteria in patients’ gut	Decreased bacteria in patients’ gut
Zhou L. China, 2014	Real-time PCR for 5 targeted genera	14 (7)	Not analyzed	Enterococcus	Bifidobacterium, Lactobacillus
Ishaq H.M. China, 2018	High-throughput sequencing	10 (10)	No differences	Prevotella 9, Haemophilus	Alistipes, Faecalibacterium, Haemophilus parainfluenzae
Yan H.X. China, 2020	High-throughput sequencing	39 (17)	Decreased Shannondiversity index	Bacilli, Lactobacillales, Prevotella, Megamonas, Veillonella	Ruminococcus, Rikenellaceae, Alistipes
Su X. China, 2020	16S rRNA gene sequencing	58 (63)	Decreased both indices of richness and diversity	7 genera including Prevotella	33 genera including Bacteroides and Alistipes
Jiang W. et al. China, 2021	16S rRNA gene sequencing	45 (59)	Decreased both indices of richness and diversity	Bacteroides, Lactobacillus	Blautia, Anaerostipes, Dorea, Eubacterium halli group, Anaerostipes, Collinsella, Ruminococcus torques group