International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Table. 5.

Table. 5.

Association between PC of perfluoroalkyl substances and thyroid hormone

TSH Total T4 Total T3 Free T4




Model 1 Model 2 Model 1 Model 2 Model 1 Model 2 Model 1 Model 2








β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI)
Total
PC 1 0.009 0.009 -0.099 -0.099 0.273 0.259 -0.009 -0.009
(-0.017, 0.036) (-0.018, 0.035) (-0.164, -0.034) (-0.164, -0.033) (-0.617, 1.163) (-0.632, 1.149) (-0.015, -0.003) (-0.015, -0.003)
PC 2 -0.032 -0.032 0.022 0.02 -0.736 -0.731 0.003 0.003
(-0.058, -0.006) (-0.058, -0.006) (-0.041, 0.085) (-0.043, 0.083) (-1.593, 0.121) (-1.589, 0.126) (-0.003, 0.008) (-0.003, 0.008)
Thyroid autoantibody status
Negative
PC1 0.021 0.02 -0.076 -0.076 0.187 0.165 -0.009 -0.009
(-0.006, 0.047) (-0.007, 0.046) (-0.144, -0.009) (-0.143, -0.008) (-0.765, 1.139) (-0.788, 1.118) (-0.015, -0.003) (-0.015, -0.003)
PC2 -0.022 -0.021 0.023 0.021 -0.659 -0.654 0.002 0.001
(-0.047, 0.003) (-0.046, 0.004) (-0.041, 0.088) (-0.043, 0.085) (-1.563, 0.245) (-1.559, 0.25) (-0.004, 0.008) (-0.004, 0.007)
Positive
PC 1 -0.012 -0.003 -0.288 -0.292 1.081 1.204 -0.018 -0.019
(-0.124, 0.099) (-0.114, 0.109) (-0.51, -0.066) (-0.515, -0.069) (-1.452, 3.614) (-1.335, 3.743) (-0.038, 0.003) (-0.04, 0.002)
PC 2 -0.133 -0.132 0.026 0.051 -1.545 -1.648 0.013 0.015
(-0.251, -0.015) (-0.251, -0.014) (-0.213, 0.265) (-0.187, 0.289) (-4.243, 1.153) (-4.355, 1.06) (-0.009, 0.036) (-0.008, 0.037)

Negative means those with neither TPO Ab nor TgAb.

Positive means those with TPO Ab or TgAb.

Model 1: Adjusted for sex, age, race/ethnicity, body mass index, smoking status, alcohol consumption, and urinary iodine concentration.

Model 2: Adjusted for the variables in Model 1 plus PC1 and PC2.

CI: confidence interval, PC: principal component, TSH: thyroid-stimulating hormone

Int J Thyroidol 2020;13:19-29 https://doi.org/10.11106/ijt.2020.13.1.19
© 2020 Int J Thyroidol