International Journal of Thyroidology

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Table. 3.

Table. 3.

Linear regression analysis with perfluoroalkyl substances and thyroid hormone

PFASs TSH Total T4 Total T3 Free T4 TPO antibodies* Tg antibodies*






β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI)
PFOA 0.012 −0.158 0.122 −0.014 −0.073 2.438
(−0.023, 0.047) (−0.244, −0.072) (−1.049, 1.294) (−0.022, −0.007) (−4.525, 4.379) (−1.792, 6.667)
PFOS −0.010 −0.083 −0.812 −0.005 2.07 3.036
(−0.04, 0.019) (−0.155, −0.012) (−1.785, 0.161) (−0.012, 0.001) (−1.624, 5.764) (−0.477, 6.549)
PFHxS −0.003 −0.015 0.913 −0.004 −0.011 2.732
(−0.03, 0.024) (−0.081, 0.051) (0.015, 1.812) (−0.01, 0.002) (−3.423, 3.4) (−0.514, 5.978)
Me-PFOSA-AcOH 0.019 −0.081 −0.462 −0.007 −0.120 1.829
(−0.014, 0.053) (−0.164, 0.001) (−1.584, 0.66) (−0.014, 0.001) (−4.387, 4.147) (−2.219, 5.877)
PFNA −0.046 −0.048 −0.316 −0.002 −0.603 3.828
(−0.083, −0.009) (−0.139, 0.043) (−1.559, 0.927) (−0.011, 0.006) (−5.331, 4.124) (−0.669, 8.324)
PFDeA −0.04 0.003 −1.162 −0.001 −0.032 1.456
(−0.078, −0.002) (−0.09, 0.096) (−2.425, 0.101) (−0.01, 0.007) (−4.84, 4.776) (−3.114, 6.026)
PFUA −0.033 0.055 −0.986 0.007 0.126 −0.692
(−0.074, 0.007) (−0.044, 0.154) (−2.33, 0.358) (−0.002, 0.016) (−4.989, 5.241) (−5.555, 4.172)

*Adjusted for sex, age, race/ethnicity, body mass index, smoking status, alcohol consumption, and urinary iodine concentration.

Adjusted for sex, age, race/ethnicity, body mass index, smoking status, alcohol consumption, urinary iodine concentration, thyroglobulin antibody and thyroperoxidase antibody.

CI: confidence interval, Me-PFOSA-AcOH: 2-(N-methyl-perfluorooctane sulfonamido) acetic acid, PFASs: perfluoroalkyl substances, PFDeA: perfluorodecanoate, PFHxS: perfluorohexane sulfonate, PFNA: perfluorononanoate, PFOA: perfluorooctanoate, PFOS:perfluorooctane sulfonate, PFUA: perfluoroundecanoate, TPO: thyroperoxidase, TSH: thyroid-stimulating hormone

Int J Thyroidol 2020;13:19-29 https://doi.org/10.11106/ijt.2020.13.1.19
© 2020 Int J Thyroidol