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Antenatal Thyroid Function Does Not Increase
Risk of Gestational Diabetes Mellitus in a
Multi-Ethnic Pregnancy Cohort
Int J Thyroidol
Published online April 23, 2020
© 2020 Korean Thyroid Association.

Christopher Alan Muir1, Ashish Munsif1, Kenrick Blaker1, Yvonne Feng2,
Mario D’Souza3 and Shailja Tewari2

Department of Endocrinology, St. Vincent’s Hospital1, Division of Medicine, The Canterbury Hospital2, Clinical Research Centre,
Sydney Local Health District3, Sydney, NSW, Australia
Correspondence to: Christopher Alan Muir, MBBS, FRACP, Department of Endocrinology, St. Vincent's Hospital,
Darlinghurst, NSW 2010, Australia
Tel: 61-283821111, Fax: 61-283823179, E-mail:
Received January 30, 2020; Revised March 24, 2020; Accepted March 30, 2020.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background and Objectives: Subclinical hypothyroidism in pregnancy has been inconsistently associated with
an increased risk of developing gestational diabetes mellitus (GDM). Materials and Methods: We retrospectively
examined whether an antenatal thyroid stimulating hormone (TSH) level ≥2.5 mIU/L was associated with
increased risk of GDM in 1147 pregnant women residing in a multi-ethnic suburban area of Sydney, Australia.
Results: Despite a high prevalence of GDM and hypothyroidism in our study, women with antenatal TSH
concentrations ≥2.5 mIU/L were not at increased risk for development of gestational diabetes. Traditional risk
factors for GDM, such as maternal body mass index, ethnicity, previous GDM pregnancy and family history
of type 2 diabetes were significant predictors of incident GDM on multivariable analyses. Conclusion: Mild
elevations in antenatal TSH concentration did not significantly increase risk of incident GDM compared to
healthy euthyroid women.
Keywords : Gestational diabetes, Hypothyroidism, Pregnancy, Maternal health, Antenatal screening

November 2020, 13 (2)