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Prognostic Significance of Sirtuins Expression in Papillary Thyroid Carcinoma
Int J Thyroidol 2018;11(2):143-151
Published online November 30, 2018;  https://doi.org/10.11106/ijt.2018.11.2.143
© 2018 Korean Thyroid Association.

Yea Eun Kang1, Minho Shong1, Jin Man Kim2 and Bon Seok Koo3

Departments of Endocrinology and Metabolism1, Pathology2, Otolaryngology-Head and Neck Surgery3, College of Medicine, Chungnam National University, Daejeon, Korea
Correspondence to: Jin Man Kim, MD, PhD, Department of Pathology, College of Medicine, Chungnam National University, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea
Tel: 82-42-280-7690, Fax: 82-42-253-4059, E-mail: jinmank@cnu.ac.kr
Bon Seok Koo, MD, PhD, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea
Tel: 82-42-280-7690, Fax: 82-42-253-4059, E-mail: bskoo515@cnuh.co.kr
Received August 14, 2018; Revised September 12, 2018; Accepted September 13, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background and Objectives: Sirtuins (SIRTs) play important roles in cellular and organismal homeostasis. They have distinct gene expression patterns in various cancers; however, the relationship between SIRT expression and the progression of thyroid cancer is unclear. We investigated the expression of SIRTs in patients with papillary thyroid carcinoma (PTC) and their role as biomarkers for predicting the aggressiveness of this disease. Materials and Methods: We used immunohistochemical staining to evaluate the expression of SIRT1 and SIRT3 in tumor specimens from 270 patients with PTC. We also evaluated the potential association between SIRT expression and diverse clinicopathological features. Results: High SIRT1 expression was negatively correlated with lymphovascular invasion, central lymph node metastasis, and lateral lymph node metastasis. Multivariate analyses revealed that high SIRT1 expression was a negative independent risk factor for lateral lymph node metastasis. By contrast, high SIRT3 expression was positively correlated with locoregional recurrence. Interestingly, when patients were grouped by tumor SIRT expression patterns, the group with low SIRT1 expression and high SIRT3 expression was correlated with more aggressive cancer phenotypes including central lymph node metastasis and lateral lymph node metastasis. Conclusion: Our results suggest that SIRTs play dual roles in tumor progression, and the combination of decreased SIRT1 expression and increased SIRT3 expression is significantly associated with a poor prognosis in patients with PTC.
Keywords : Papillary thyroid carcinoma, SIRT1, SIRT3, Sirtuin, Tumor progression


November 2018, 11 (2)