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Real-Time Localization of Parathyroid Glands with Near Infrared Light during Thyroid and Parathyroid Surgery
Int J Thyroidol 2018;11(2):92-98
Published online November 30, 2018;
© 2018 Korean Thyroid Association.

Sung Won Kim1, Yeong Wook Jeong1, Yoon Woo Koh2 and Kang Dae Lee1

Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine1, Busan, Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University College of Medicine2, Seoul, Korea
Correspondence to: Kang Dae Lee, MD, PhD, Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea
Tel: 82-51-990-6470, Fax: 82-51-245-8539, E-mail:
Received August 9, 2018; Revised October 22, 2018; Accepted October 23, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Intraoperative identification and localization of parathyroid glands are crucial step in preventing postoperative hypocalcemia during thyroid and parathyroid surgery. If there is a method to predict the parathyroid’s location rather than detecting and verifying with naked eye, it would make the operator easier to find and identify the parathyroid. Recently, near-infrared light imaging technologies have been introduced in the fields of thyroid and parathyroid surgery to predict the localization of the parathyroid. These are being conducted in two ways: autofluorescence imaging with a unique intrinsic fluorophore in the parathyroid tissues and fluorescence imaging with external fluorescence materials specially absorbed into parathyroid tissues. We are suggest that parathyroid glands can be detected by surgeon with NIR autofluorescence imaging even if they are covered by fibrofatty tissues before they are detected by surgeon’s naked eye. These novel techniques are very useful to identify and preserve parathyroid glands during thyroidectomy. In this article, we reviewed the latest papers that describe autofluorescence imaging and exogenous ICG fluorescence imaging of parathyroid glands during thyroid and parathyroid surgery.
Keywords : Parathyroid, Autofluorescence, Fluorescence, Near-infrared, Indocyanine green

November 2018, 11 (2)