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Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers
Int J Thyroidol 2018;11(1):41-48
Published online May 30, 2018;  https://doi.org/10.11106/ijt.2018.11.1.41
© 2018 Korean Thyroid Association.

In Hye Chae1,2, Eun-Kyung Kim2, Hee Jung Moon2, Jung Hyun Yoon2, Vivian Y. Park2, Hye Sun Lee3, Jieun Moon3 and Jin Young Kwak2

Department of Radiology, National Cancer Center1, Goyang, Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine2, Biostatistics Collaboration Unit, Medical Research Center, Yonsei University College of Medicine3, Seoul, Korea
Correspondence to: Jin Young Kwak, MD, PhD, Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Tel: 82-2-2228-2355, Fax: 82-2-393-3035, E-mail: docjin@yuhs.ac
Received July 14, 2017; Revised April 20, 2018; Accepted May 9, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background and Objectives: The present study investigated the association between preoperative neutrophilto-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.
Keywords : Lymphocyte, Lymph node metastasis, Neutrophil, Recurrence, Papillary thyroid carcinoma