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Secular Trends for Diagnostic Motives and Environmental Risk Factors in Thyroid Cancer Using Questionnaire Survey
Int J Thyroidol 2017;10(2):82-88
Published online November 30, 2017;
© 2017 Korean Thyroid Association.

Hana Kim1*, Yul Hwangbo2*, Sung Hye Kong1, Young Shin Song1, Min Joo Kim1, Sun Wook Cho1, You Jin Lee2, Ka Hee Yi3, Do Joon Park1,4, Eun Kyung Lee2 and Young Joo Park1

Department of Internal Medicine, Seoul National University College of Medicine1, Seoul, Center for Thyroid Cancer, National Cancer Center2, Goyang, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center3, Seoul, Korea National Institute of Health4, Cheongju, Korea
Correspondence to: Eun Kyung Lee, MD, PhD, Center for Thyroid Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea
Tel: 82-31-920-1743, Fax: 82-31-920-2798, E-mail:
*These two authors equally contributed to this article.
Received November 13, 2017; Revised November 14, 2017; Accepted November 15, 2017.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background and Objectives: We analyzed the clinicopathologic differences of thyroid cancer by diagnosis periods, diagnostic motives, residence history and clinical risk factors in thyroid cancer patients. Materials and Methods: Total 1599 thyroid cancer patients who answered the questionnaires about family history of thyroid cancer, residence history including duration of residence and location were enrolled from two hospitals, Seoul National University Hospital and National Cancer Center in Korea. Demographics and environmental information were collected via questionnaires and clinical data were reviewed via electronic medical records. Results: More thyroid cancer has been diagnosed in 2011 to 2013 by screening test without specific symptom than before 1990. The size of cancer at diagnosis was significantly smaller and multifocal tumor was more frequently found in 2011 to 2013 than before 1990 as well. The tumors of obese or overweight patients tended to harbor extrathyroidal extension and lymph node metastasis than normal weight subjects with statistical significance. However, there were no differences in clinicopathologic characteristics according to residence and smoking history. Conclusion: In this study, there were some different clinicopathologic characteristics according to the diagnosis era, diagnostic motives, family history of thyroid cancer and body mass index.
Keywords : Thyroid cancer, Thyroid cancer screening, Environmental factor, Questionnaire

November 2018, 11 (2)