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Clinical Value of Blood Neutrophil to Lymphocyte Ratio in Patients with Papillary Thyroid Carcinoma with Neck Lymph Node Metastasis
Int J Thyroidol
Published online October 12, 2017
© 2017 Korean Thyroid Association.

Hwa Bin Kim1, Hyoung Shin Lee2, Sung Won Kim2, Seok Won Jeon2, Ji Ah Song2 and Kang Dae Lee2

Department of Medicine, Kosin University College of Medicine1, Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine2, Busan, Korea
Correspondence to:

Kang Dae Lee, MD

Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, 262, Gamcheon-ro, Seo-gu, Busan 49267, Korea
Tel: 82-51-990-6470, Fax: 82-51-245-8539, E-mail:

Received June 16, 2017; Revised August 4, 2017; Accepted August 10, 2017.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background and Objectives: Blood neutrophil-to-lymphocyte ratio (NLR) has been reported to have poor prognostic impact in variable malignancies. However, studies evaluating the clinical significance of blood NLR in patient with papillary thyroid carcinoma (PTC) has been relatively rare, and the outcomes were inconsistent. In this study, we sought to analyze the clinical value of NLR in patients with PTC who had cervical lymph node metastasis. Materials and Methods: Retrospective chart review was conducted with 174 patients with confirmed neck metastasis of PTC after initial thyroidectomy. Blood NLR was estimated by dividing the absolute number of blood neutrophil with that of lymphocyte. Statistical analysis was conducted to evaluate correlation between NLR and clinicopathologic factors, patterns of metastatic lymph nodes, and recurrence. Results: Higher NLR (>1.74) was correlated to younger age of patients (<45 years, p=0.045) and smaller size of tumor (<1 cm, p=0.017). Blood NLR had no impact on patterns of lymph node metastasis or recurrence. Conclusion: Blood NLR may not be considered as a predictive factor for clinical aggressiveness or prognosis in patients with PTC with lymph node metastasis.
Keywords : Papillary thyroid carcinoma, Neck metastasis, Neutrophil, Lymphocyte