International Journal of Thyroidology

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Table. 1.

Table. 1.

Clinicopathological features of TC in coexisting TC and RCC group and TC alone group

TC characteristics TC and RCCn=53 (0.4%) TC alonen=13,663 p value
Age, years
Mean±SD 53.6±11.7 47.2±11.6
Median (IQR) 54.0 (17) 47.0 (16) <0.001
Sex <0.001
Male 26 (49.1) 2,688 (19.7)
Female 27 (50.9) 10,975 (80.3)
Family history of any cancer 17 (32.1) 47 (0.4) <0.001
Tumor size, cm (range) 0.9 (0.2-4.0) 0.8 (0.05-13.0) 0.164
Multifocality 24 (45.3) 4,415 (32.4) 0.046
Pathologic stage* 0.003
Stage 1 19 (35.8) 7,994 (59.0)
Stage 2 0 (0) 171 (1.3)
Stage 3 30 (56.6) 4,375 (32.3)
Stage 4 4 (7.5) 1,014 (7.5)
LN metastasis 23 (43.4) 5,635 (41.7) 0.805
Distant metastasis 1 (1.9) 102 (0.7) 0.330
Operation type 0.081
TT w/ or w/o CND 42 (79.2) 8,640 (64.5)
TT with MRND 4 (7.5) 1,848 (13.8)
Lobectomy 7 (13.2) 2,902 (21.7)
Others 0 (0) 273 (2.0)
Extrathyroidal extension 32 (60.4) 11,749 (86.0) <0.001
Lymphatic invasion 0 (0) 247 (1.8) 1.000
Vascular invasion 0 (0) 318 (2.3) 0.637
Histologic subtype 0.146
PTC 49 (92.5) 13,183 (96.9)
FTC 3 (5.7) 278 (2.0)
MTC 1 (1.9) 119 (0.9)
ATC 0 (0) 21 (0.2)
Others 0 61 (0.4)
RAI therapy 39 (73.6) 9,073 (66.2) 0.182
Total RAI dose, mCi (range) 100 (30-550) 100 (20-1400) 0.519
F/U duration of TC, months (range) 60.8 (4.9-163.7) 73.5 (0.1-681.3) 0.078

ATC: anaplastic thyroid cancer, CND: central neck dissection, F/U: follow up, FTC: follicular thyroid cancer, IQR: interquartile range, LN: lymph node, MRND: modified radical neck dissection, MTC: medullary thyroid cancer, PTC: papillary thyroid cancer, RAI: radioactive iodine, RCC: renal cell carcinoma, SD: standard deviation, TC: thyroid cancer, TT: total thyroidectomy, w/: with, w/o: without

Data available for family history of any cancer (n=12,052), tumor size (n=13,647), multifocality (n=13,624), pathologic stage (n=13,554), LN metastasis (n=13,506), distant metastasis (n=13,554), extrathyroidal extension (n=13,404), lymphatic invasion (n=13,582), vascular invasion (n=13,577), RAI therapy (n=8,731) in TC alone group.

*Staging according to the American Joint Committee on Cancer (AJCC) Thyroid Cancer Staging System 7th edition.

Int J Thyroidol 2021;14:28-36 https://doi.org/10.11106/ijt.2021.14.1.28
© 2021 Int J Thyroidol