International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Table. 1.

Table. 1.

Baseline characteristics of study subjects according to changes of nodule size

Size of thyroid nodule Total No change Decreased Increased
N (%) 7753 5817 (75.0) 895 (11.5) 1041 (13.5)
Sex
Male (%) 3235 (41.7) 2452 (42.2) 390 (43.6) 393 (37.8)§
Female (%) 4518 (58.3) 3365 (57.8) 505 (56.4) 648 (62.2)§
Age (years), mean±SD 52.1±9.4 52.1±9.4 52.1±9.5 51.7±9.5
<40 694 (9.0) 513 (8.8) 78 (8.7) 103 (9.9)
40-59 5385 (69.5) 4050 (69.6) 604 (67.5) 731 (70.2)
≥60 1674 (21.5) 1254 (21.6) 213 (23.8) 207 (19.9)
Numbers of thyroid ultrasound, mean±SD 3.1±1.4 3.0±1.4 2.9±1.3 3.5±1.7§
Duration of follow up (months), mean±SD (median, ranges) 32.4±20.7 (27.0, 3.0-91.3) 30.8±20.3 (25.7, 3.0-91.3) 36.1±21.1 (35.2, 3.0-87.4) 39.1±21.3§ (37.1, 3.0-91.3)
Size at baseline (mm), mean±SD 8.2±5.7 7.5±4.9 11.5±7.3 9.1±7.1§
<5.0 2165 (27.9) 1750 (30.1/80.8) 125 (14.0/5.8) 290 (27.9/13.4)§
5.0-9.9 3618 (46.7) 2859 (49.1/79.0) 316 (35.3/8.7) 443 (42.6/12.2)§
10.0-19.9 1595 (20.6) 1029 (17.7/64.5) 346 (38.7/21.7) 220 (21.1/13.8)§
≥20.0 375 (4.8) 179 (3.1/47.7) 108 (12.1/28.8) 88 (8.5/23.5)§
Diffuse parenchymal abnormality (%)* 8.2 6.7 15.3 10.5§
TSH (mU/L), mean±SD 2.0±3.1 2.0±3.4 2.1±2.6 1.9±1.8§
<0.4 193 (2.6) 118 (2.1) 38 (4.5) 37 (3.7)§
0.4-4.1 6831 (91.8) 5183 (92.5) 752 (89.1) 896 (89.7)§
>4.1 420 (5.6) 300 (5.4) 54 (6.4) 65 (6.6)§
Free T4 (ng/dL), mean±SD 1.24±0.30 1.23±0.28 1.26±0.43 1.23±0.24
Smoking (ex-smoker or current smoker) (%) 38.1 38.3 37.8 36.9
Systolic blood pressure (mmHg), mean±SD 117.9±16.2 117.7±16.1 118.4±15.6 118.4±16.8
Diastolic blood pressure (mmHg), mean±SD 75.8±11.9 75.7±11.9 76.4±11.6 76.2±12.2
Body mass index (kg/m2), mean±SD 23.4±2.9 23.4±2.9 23.6±2.9 23.4±2.9
Waist circumference (cm), mean±SD 84.5±8.1 84.5±8.1 84.9±8.1 84.3±8.1
Body fat (%) 26.5±5.7 26.4±5.7 26.7±5.7 27.0±5.6
Fasting glucose (mg/dL) 98.1±17.9 97.9±17.9 98.7±17.3 98.7±18.0
HbA1c 5.74±0.60 5.75±0.61 5.75±0.54 5.72±0.61
<6.5% 6791 (92.9) 5128 (93.1) 765 (93.1) 898 (91.7)
≥6.5% 520 (7.1) 382 (6.9) 57 (6.9) 81 (8.3)
Total cholesterol (mg/dL) 198.2±34.1 197.8±34.0 200.8±33.9 198.7±35.2

*Diffuse parenchymal abnormality defined as heterogenous echogenicity in sonography.

Significant changes of nodule were defined when the nodules increased or decreased at least 3 mm from their initial size during follow-up period.

No change vs. decreased.

§No change vs. increased.

SD: standard deviation

Int J Thyroidol 2020;13:118-27 https://doi.org/10.11106/ijt.2020.13.2.118
© 2020 Int J Thyroidol