International Journal of Thyroidology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2466-1899   pISSN 2384-3799

Table. 2.

Table. 2.

Baseline characteristics of study subjects according to changes of nodule size in thyroid nodules 1 cm

Total No change Decreased Increased
N 1970 1208 (61.3) 454 (23.0) 308 (15.6)
Sex
Male (%) 784 (39.8) 465 (38.5) 203 (44.7) 116 (37.7)
Female (%) 1186 (60.2) 743 (61.5) 251 (55.3) 192 (62.3)
Age (years old) 53.2±9.7 53.4±9.7 53.7±9.6 52.0±10.1§
<40 145 (7.4) 83 (6.9) 30 (6.6) 32 (10.4)
40-59 1310 (66.5) 809 (67.0) 293 (64.5) 208 (67.5)
≥60 515 (26.1) 316 (26.2) 131 (28.9) 68 (22.1)
Numbers of thyroid sonography 3.0±1.4 2.9±1.4 3.2±1.5 3.3±1.7§
Duration of follow up (months)mean±SD (median, ranges) 32.5±21.1 (27.8, 3.0-90.7) 30.2±20.8 (25.2, 3.0-90.7) 35.6±21.2 (35.1, 3.0-87.4) 36.1±20.5§ (35.0, 3.0-85.9)
Initial nodule size (mm) 15.6±6.5 14.9±5.9 16.5±7.0 17.0±7.7§
10.0-19.9 1595 (81.0) 1029 (64.5) 346 (21.7) 220 (13.8)§
≥20.0 375 (19.0) 179 (47.7) 108 (28.8) 88 (23.5)
Diffuse parenchymal abnormality (%) 8.6 7.5 10.8 9.6
TSH (mU/L) 1.93±2.76 1.91±2.87 2.10±3.16 1.78±1.27
<0.4 65 (3.6) 31 (2.8/47.7) 16 (3.9/24.6) 18 (6.4/27.7)§
0.4-4.1 1654 (91.3) 1030 (92.5/62.3) 375 (90.4/22.7) 249 (88.0/15.0)
>4.1 93 (5.1) 53 (4.8/57.0) 24 (5.8/25.8) 16 (5.7/17.2)
Free T4 (ng/dL) 1.24±0.33 1.23±0.33 1.25±0.38 1.25±0.25
Smoking (ex-smoker or current smoker) (%) 36.9 36.5 38.0 36.4
Systolic blood pressure (mmHg) 118.9±16.4 118.5±16.6 119.8±16.0 119.2±16.4
Diastolic blood pressure (mmHg) 76.0±11.6 75.6±11.8 77.2±11.3 75.7±11.3
Body mass index (kg/m2) 23.6±2.9 23.6±2.9 23.7±3.0 23.7±2.8
Waist circumference (cm) 85.0±8.2 85.0±8.2 85.2±8.3 84.7±8.2
Body fat (%) 27.1±5.8 27.0±5.9 27.0±5.7 27.7±5.5
Fasting glucose (mg/dL) 99.4±19.2 98.6±20.7 98.6±15.5 99.8±17.9
HbA1c 5.79±0.64 5.81±0.69 5.73±0.50 5.76±0.65
<6.5% 1627 (91.4) 993 (90.5) 379 (93.6) 255 (91.4)
≥6.5% 154 (8.6) 104 (9.5) 26 (6.4) 24 (8.6)
Total cholesterol (mg/dL) 198.4±34.9 197.4±34.3 200.4±33.9 199.3±38.1

*Diffuse parenchymal abnormality defined as heterogenous echogenicity in sonography.

Significant changes of nodule were defined when the nodules increased or decreased at least 3 mm from theirinitial size during follow-up period.

No change vs. decreased.

§No change vs. increased.

SD: standard deviation

Int J Thyroidol 2020;13:118-27 https://doi.org/10.11106/ijt.2020.13.2.118
© 2020 Int J Thyroidol